GEFs help Rabs find their target
نویسندگان
چکیده
منابع مشابه
Help Developers (finally) Find Their Own Performance Defects
How early in the software development cycle are most performance defects found? Before or after QA? Industry pundits have long sought to reduce costs by fixing software defects earlier in the cycle. The path to these cost reductions, however, is fraught with road blocks. This paper focuses on a concrete testing regimen that works around these longstanding obstacles. It empowers developers to fi...
متن کاملRabs and their effectors: achieving specificity in membrane traffic.
Rab proteins constitute the largest branch of the Ras GTPase superfamily. Rabs use the guanine nucleotide-dependent switch mechanism common to the superfamily to regulate each of the four major steps in membrane traffic: vesicle budding, vesicle delivery, vesicle tethering, and fusion of the vesicle membrane with that of the target compartment. These different tasks are carried out by a diverse...
متن کاملResearchers Find Their Nemo
With its genome almost fully sequenced, the zebrafish has gone from bit player to rising star among model organisms. Its lower maintenance costs and the ease of tissue imaging in live zebrafish are among the benefits that have cast this organism as an emerging player in disease research and drug screening.
متن کاملInteractions between Rabs, tethers, SNAREs and their regulators in exocytosis.
Sec2p is the exchange factor that activates Sec4p, the Rab GTPase controlling the final stage of the yeast exocytic pathway. Sec2p is recruited to secretory vesicles by Ypt32-GTP, a Rab controlling exit from the Golgi. Sec15p, a subunit of the octameric exocyst tethering complex and an effector of Sec4p, binds to Sec2p on secretory vesicles, displacing Ypt32p. Sec2p mutants defective in the reg...
متن کاملColor Targets: Fiducials to Help Visually Impaired People Find Their Way by Camera Phone
A major challenge faced by the blind and visually impaired population is that of wayfinding—the ability of a person to find his or her way to a given destination. We propose a new wayfinding aid based on a camera cell phone, which is held by the user to find and read aloud specially designed machine-readable signs, which we call color targets, in indoor environments (labeling locations such as ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2013
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.2003iti2